MovDisordV3, Main, Exploration, bibRecord, 003E16

Anti‐basal ganglia antibodies in PANDAS

Identifieur interne : 003E16 ( Main/Exploration ); précédent : 003E15; suivant : 003E17

Anti‐basal ganglia antibodies in PANDAS

Auteurs : Harvey S. Singer [États-Unis] ; Christopher R. Loiselle [États-Unis] ; Olivia Lee [États-Unis] ; Karen Minzer [États-Unis] ; Susan Swedo [États-Unis] ; Franz H. Grus [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2004-04.

RBID : ISTEX:039CA62422D3E05428CCCBC1F35F31AE06E183B0

Descripteurs français

Pascal (Inist)
- Noyau gris central, Système nerveux pathologie.

English descriptors

KwdEn :
- Adolescent, Antibodies, Anti-Idiotypic (immunology), Autoimmune Diseases (immunology), Autoimmune Diseases (microbiology), Basal Ganglia (immunology), Basal Ganglia (pathology), Basal ganglion, Blotting, Western, Brain (immunology), Brain (microbiology), Child, Child, Preschool, ELISA, Enzyme-Linked Immunosorbent Assay, Female, Globus Pallidus (immunology), Globus Pallidus (pathology), Humans, Male, Mental Disorders (microbiology), Nervous system diseases, PANDAS, Streptococcal Infections (complications), Streptococcal Infections (immunology), Tics (immunology), Tics (microbiology), Western blot, anti‐basal ganglia antibodies, discriminant analysis.
MESH :
- chemical , immunology : Antibodies, Anti-Idiotypic.
- complications : Streptococcal Infections.
- immunology : Autoimmune Diseases, Basal Ganglia, Brain, Globus Pallidus, Streptococcal Infections, Tics.
- microbiology : Autoimmune Diseases, Brain, Mental Disorders, Tics.
- pathology : Basal Ganglia, Globus Pallidus.
- Adolescent, Blotting, Western, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male.

Abstract

An autoimmune‐mediated mechanism involving molecular mimicry has been proposed for a variety of pediatric movement disorders that occur after a streptococcal infection. In this study, anti‐basal ganglia antibodies (ABGA) were measured in 15 children with the diagnosis of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and compared with those in 15 controls. ELISA and Western immunoblotting (WB) methods were used to detect ABGA against supernatant (S1), pellet (P2), and synaptosomal preparations from adult postmortem caudate, putamen, and globus pallidus. ELISA optical density values did not differ between PANDAS patients and controls across all preparations. Immunoblotting identified multiple bands in all subjects with no differences in the number of bands or their total density. Discriminant analysis, used to assess mean binding patterns, showed that PANDAS patients differed from controls only for the caudate S1 fraction (Wilks' λ = 0.0236, P < 0.0002), with PANDAS‐primarily tic subjects providing the greatest discrimination. Among the epitopes contributing to differences between PANDAS and control in the caudate S1 fraction, mean binding to the epitope at 183 kDa was the most different between groups. In conclusion, ELISA measurements do not differentiate between PANDAS and controls, suggesting a lack of major antibody changes in this disorder. Further immunoblot analyses using a caudate supernatant fraction are required to completely exclude the possibility of minor antibody repertoire differences in PANDAS subjects, especially in those who primarily have tics. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/039CA62422D3E05428CCCBC1F35F31AE06E183B0/fulltext/pdf

DOI: 10.1002/mds.20052

Affiliations:

Le document en format XML

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<author><name sortKey="Loiselle, Christopher R" sort="Loiselle, Christopher R" uniqKey="Loiselle C" first="Christopher R." last="Loiselle">Christopher R. Loiselle</name>
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<author><name sortKey="Lee, Olivia" sort="Lee, Olivia" uniqKey="Lee O" first="Olivia" last="Lee">Olivia Lee</name>
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<author><name sortKey="Minzer, Karen" sort="Minzer, Karen" uniqKey="Minzer K" first="Karen" last="Minzer">Karen Minzer</name>
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<author><name sortKey="Swedo, Susan" sort="Swedo, Susan" uniqKey="Swedo S" first="Susan" last="Swedo">Susan Swedo</name>
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<term>Autoimmune Diseases (immunology)</term>
<term>Autoimmune Diseases (microbiology)</term>
<term>Basal Ganglia (immunology)</term>
<term>Basal Ganglia (pathology)</term>
<term>Basal ganglion</term>
<term>Blotting, Western</term>
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<term>Humans</term>
<term>Male</term>
<term>Mental Disorders (microbiology)</term>
<term>Nervous system diseases</term>
<term>PANDAS</term>
<term>Streptococcal Infections (complications)</term>
<term>Streptococcal Infections (immunology)</term>
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<front><div type="abstract" xml:lang="en">An autoimmune‐mediated mechanism involving molecular mimicry has been proposed for a variety of pediatric movement disorders that occur after a streptococcal infection. In this study, anti‐basal ganglia antibodies (ABGA) were measured in 15 children with the diagnosis of pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and compared with those in 15 controls. ELISA and Western immunoblotting (WB) methods were used to detect ABGA against supernatant (S1), pellet (P2), and synaptosomal preparations from adult postmortem caudate, putamen, and globus pallidus. ELISA optical density values did not differ between PANDAS patients and controls across all preparations. Immunoblotting identified multiple bands in all subjects with no differences in the number of bands or their total density. Discriminant analysis, used to assess mean binding patterns, showed that PANDAS patients differed from controls only for the caudate S1 fraction (Wilks' λ = 0.0236, P < 0.0002), with PANDAS‐primarily tic subjects providing the greatest discrimination. Among the epitopes contributing to differences between PANDAS and control in the caudate S1 fraction, mean binding to the epitope at 183 kDa was the most different between groups. In conclusion, ELISA measurements do not differentiate between PANDAS and controls, suggesting a lack of major antibody changes in this disorder. Further immunoblot analyses using a caudate supernatant fraction are required to completely exclude the possibility of minor antibody repertoire differences in PANDAS subjects, especially in those who primarily have tics. © 2004 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Anti‐basal ganglia antibodies in PANDAS

Anti‐basal ganglia antibodies in PANDAS

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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